Capsaicin - 10 Things You Should Know About CapsaicinCapsaicin - 10 Things You Should Know Topical Cream Relieves Arthritis Pain. By Carol Eustice, About.com Guide. Updated March 04, 2009. About.com Health's ...Capsaicin Cream - What is Capsaicin Cream?Rheumatoid arthritis. When it is applied to the skin, capsaicin cream has been found to deplete substance P—a neurochemical that transmits pain—which ...Arthritis cream: capsaicin derived from cayenne or red pepperCayenne or red peppers contain a substance called 'capsaicin' that is often used as the active ingredient in arthritis cream. Cayenne peppers (also known as red ...